Hyperparathyroidism

Conclusions  In long-term normoalbuminemic Japanese hemodialysis patients, with low prevalence of inflammation, OPG levels were strongly linked with both arterial stiffness and worse outcome. Content Type Journal ArticleDOI 10.1007/s00198-010-1377-0Authors A. Nakashima, Department of Advanced Nephrology, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi Minami-Ku, Hiroshima, 734-8551 JapanJ. J. Carrero, Divisions of Renal Medicine and Baxter Novum, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, SwedenA. R. Qureshi, Divisions of Renal Medicine and Baxter Novum, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, SwedenT. Hirai, Department of Internal Medi...

(Source: NLH - ENT and Audiology - Events)

Abstract (Source: Arthritis and Rheumatism)

Abstract: Endocrine disorders are increasingly encountered in pregnancy. To optimize pregnancy outcome, it is essential to understand the physiology underlying these conditions, as well as which investigations and treatments are safe to use. Thyroid disease is the second most common endocrine condition encountered in women of childbearing age after diabetes. Other endocrine disorders, such as pituitary dysfunction and adrenal and parathyroid disease, are less frequently encountered in pregnancy due to lower population prevalence in combination in some cases with associated subfertility. Women whose pregnancies are complicated by endocrine disease are at risk of maternal and foetal complications, but these can be minimized with appropriate multidisciplinary management. (Source: Obstetrics, ...

PTH stimulates osteoblastic cells to form new bone and to produce osteoblast-osteoclast coupling factors such as RANKL. Whether osteoclasts or their activity are needed for PTH anabolism remains uncertain. We treated ovariectomized huRANKL knock-in mice with a human RANKL inhibitor denosumab (DMAb), alendronate (Aln), or vehicle for 4 weeks, followed by co-treatment with intermittent PTH for 4 weeks. Loss of bone mass and microarchitecture was prevented by Aln and further significantly improved by DMAb. PTH improved bone mass, microstructure, and strength, and was additive to Aln but not to DMAb. Aln inhibited biochemical and histomorphometrical indices of bone turnover, -i.e. osteocalcin and bone formation rate (BFR) on cancellous bone surfaces-, and Dmab inhibited them further. However A...

MicroRNAs (miRs) represent a class of endogenous ~18–25 nucleotide RNAs that regulate gene expression through translational repression by binding to a target mRNA. These miRs regulate several biological functions, such as cell growth, cell differentiation, carcinogenesis, and so on. In a previous report, we have indicated that miR-141 and -200a act as preosteoblast differentiation modulators. In the present study, using microRNA array and in silico analyses, we found that miR-208 is closely involved in preosteoblast differentiation by partially regulating the expression of Ets1 (V-ets erythroblastosis virus E26 oncogene homolog 1), which transactivates osteopontin, runt-related transcription factor 2, parathyroid hormone-related protein, and type I procollagen. Furthermore, the enfor...

MicroRNAs (miRs) represent a class of endogenous ~18–25 nucleotide RNAs that regulate gene expression through translational repression by binding to a target mRNA. These miRs regulate several biological functions, such as cell growth, cell differentiation, carcinogenesis, and so on. In a previous report, we have indicated that miR-141 and -200a act as preosteoblast differentiation modulators. In the present study, using microRNA array and in silico analyses, we found that miR-208 is closely involved in preosteoblast differentiation by partially regulating the expression of Ets1 (V-ets erythroblastosis virus E26 oncogene homolog 1), which transactivates osteopontin, runt-related transcription factor 2, parathyroid hormone-related protein, and type I procollagen. Furthermore, the enfor...

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We read the article by Goasguen and colleagues and discussed it with interest in our journal club. We congratulate the authors for rejuvenating the concept of parathyroid microadenomas. However, there were certain queries raised during our discussion and it would be fruitful if we get a timely reply. (Source: Journal of the American College of Surgeons)

We thank Chand and colleagues for their thoughtful comments on our article “Primary Hyperparathyroidism Due to Parathyroid Microadenoma: Specific Features and Implications for a Surgical Strategy in the Era of Minimally Invasive Parathyroidectomy.” We provide a point-by-point answer to the queries raised. (Source: Journal of the American College of Surgeons)

Conclusion  The intraoperative probe technique is feasible in patients with pHPT and limited diagnostics for the location of parathyroid adenomas with concomitant goiter. This diagnostic technique identified the parathyroid adenoma in all cases, and thus rendered a bilateral neck exploration obsolete. Content Type Journal ArticleDOI 10.1007/s00595-009-4144-0Authors Wolfgang Sendt, Department of General and Visceral Surgery, Krankenhaus St. Joseph Stift, Schwachhauser Heerstrasse 54, 28209 Bremen, GermanyKnut Spieker, Outpatient Center for Endocrinology, Bremen, GermanyGertrud Michael, Center for Nuclear Medicine and PET/CT, Bremen, GermanyKarin Jandt, Department of General, Visceral and Vascular Surgery, University Hospital Jena, Jena, GermanyAnnelore Altendorf-Hofma...

Conclusions  In addition to the nutritional assessment, regular monitoring of bone markers seems necessary in these patients and the early introduction of preventive strategies (i.e., the use of antiresorptive agents) should be evaluated. Content Type Journal ArticleDOI 10.1007/s11695-010-0257-1Authors Fernando Granado-Lorencio, Unidad de Vitaminas, Hospital Universitario Puerta de Hierro-Majadahonda, 28222 Madrid, SpainAlberto Simal-Antón, Servicio de Endocrinología y Nutrición, Hospital Universitario Puerta de Hierro-Majadahonda, 28222 Madrid, SpainJavier Salazar-Mosteiro, Servicio de Bioquímica Clínica, Hospital Universitario Puerta de Hierro-Majadahonda, 28222 Madrid, SpainCarmen Herrero-Barbudo, Unidad de Vitaminas, Hospital Universitario Puerta de Hierro-Ma...

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Conclusion: PTH 1-84 improves pain, mobility, and fracture repair in adult HPP, even after repeat treatment. Residual activity of the p.E191K ALPL gene mutation could explain why PTH can stimulate S-ALP. P-Pi concentrations may modulate the response. PMID: 20739387 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)

Conclusion: 19 hospitals used 18 different study protocols. Thus, significant variability exists in the current practice of PS in Finland. The protocols should be tested with known phantoms to determine any differences in sensitivities for detecting small active structures. Further studies with phantoms are needed to determine the optimal imaging techniques. The results of these phantom studies will provide guidelines for proposing national recommendations for PS. PMID: 20737112 [PubMed - as supplied by publisher] (Source: Nuklearmedizin)

Authors: Saji F, Shigematsu T, Sakaguchi T, Ohya M, Orita H, Maeda Y, Ooura M, Mima T, Negi S Fibroblast growth factor 23 (FGF23), which is primarily produced by osteocytes in bone, regulates renal phosphate excretion and 1alpha,25-dihydroxyvitamin D [1,25(OH)(2)D(3)] metabolism. Patients with chronic kidney disease (CKD) have increased levels of circulating serum FGF23, but the direct effect on circulating FGF23 levels in renal insufficiency is still unclear. To identify the major regulator of FGF23 synthesis in renal insufficiency, we compared the effect of parathyroid hormone (PTH) and 1,25(OH)(2)D(3) on FGF23 synthesis in the calvaria of normal rats with that of uremic rats in vitro. 1,25(OH)(2)D(3) treatment significantly increased the FGF23 concentration in the medium from both g...

Conclusions. These in vitro findings demonstrate that lanthanum, at nanomolar concentrations, is an agonist of the CaSR able to activate it in the absence of calcium. In addition, it can also enhance CaSR sensitivity to calcium, modulating PTH synthesis and secretion. (Source: Nephrology Dialysis Transplantation)

Conclusions. Elevated ALP is associated with increased mortality in patients with pre-dialysis CKD. Low ALP appears to be associated with short-term mortality. (Source: Nephrology Dialysis Transplantation)

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Conclusions. In primary analysis, serum FGF23 was not associated with increased mortality risk in this cohort of ‘incident’ dialysis patients. Our data support that the impact of FGF23 on mortality may be modified by gender and CVD and, as previously shown, is blunted in the setting of pronounced hyperphosphatemia. (Source: Nephrology Dialysis Transplantation)

Conclusion. In this large 2008 cohort of elderly haemodialysis patients, it appears easier to control serum parameters of CKD-MBD as compared to younger dialysis patients. A better control of serum phosphorus was observed, with less phosphate binder and reduced cinacalcet dosage. (Source: Nephrology Dialysis Transplantation)

Conclusion  This study revealed majority of thalassemics with inadequate chelation have bone resorption with advancing chronological age and BMD should be evaluated regularly for early diagnosis to prevent morbidity. Content Type Journal ArticleDOI 10.1007/s12098-010-0158-2Authors Rashid Merchant, Department of Pediatrics, Dr Balabhai Nanavati hospital Mumbai, 501, Rangmahal 5th floor, 2 Mount mary road, Bandra (west), Mumbai, 400050 IndiaAmish Udani, Department of Pediatrics, Dr Balabhai Nanavati hospital Mumbai, 501, Rangmahal 5th floor, 2 Mount mary road, Bandra (west), Mumbai, 400050 IndiaVipla Puri, Department of RIA, P. D. Hinduja National Hospital and Medical Research Centre Mumbai, Mumbai, IndiaValentina D’cruz, Department of RIA, P. D. Hinduja National Hosp...

Conclusion  OPN levels are related to the anabolic effect of PTH in human postmenopausal osteoporosis. Plasma OPN levels could be used as a biomarker for early treatment response. Content Type Journal ArticleDOI 10.1007/s00198-010-1327-xAuthors T.-I. Chiang, Institute of Medicine, Chung Shan Medical University, No. 110, Sec. 1, Jianguo, N. Rd, Taichung, 40201 TaiwanI.-C. Chang, Institute of Medicine, Chung Shan Medical University, No. 110, Sec. 1, Jianguo, N. Rd, Taichung, 40201 TaiwanH.-S. Lee, Department of Public Health, College of Health Care and Management, Chung Shan Medical University, Taichung, TaiwanH. Lee, Institute of Medicine, Chung Shan Medical University, Taichung, TaiwanC.-H. Huang, Institute of Medicine, Chung Shan Medical University, No. 110, Sec. ...